Neuroprotective Effect of Pyridoxine Hydrochloride in Models of Mononeuropathy in Rats
نویسندگان
چکیده
We have evaluated the neuroprotective actions of Pyridoxine hydrochloride 100mg/kg (PYR) by using partial sciatic nerve ligation (PSNL) and sciatic nerve crush injury (SNCI) models in wistar rats. The parameters used were thermal hyperalgesia (TH), motor function test (MFT) and motor nerve conduction velocity (MNCV). A steady improvement in TH was seen in PYR treated animals on day 21 (10.01±0.23) and day 14 (10.36±0.2 s) in the models of PSNL and SNCI respectively. There was a reduction in pain which was observed behaviorally in MFT in both the models and also a steady improvement in MNCV of PYR treated animals which improved on 15 day (30.39 ± 1.78m/s) and 30 (40.59± 2.54m/s) indicating that PYR has a considerable neuroprotective action in PSNL and SNCI in rats.
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تاریخ انتشار 2007